Application of molecularly imprinted polymers in analytical chiral separations and analysis
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چکیده
منابع مشابه
Chiral separations of mandelic acid by HPLC using molecularly imprinted polymers
Styrene is used in a variety of chemical industries. Environmental and occupational exposures to styrene occur predominantly through inhalation. The major metabolite of styrene is present in two enantiomeric forms, chiral Rand Shydroxy-1-phenyl-acetic acid (R-and S-mandelic acid, MA). Thus, the concentration of MA, particularly of its enantiomers, has been used in urine tests to determine wheth...
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Molecularly imprinted technology (MIT) has the characteristics of specificity and high selectivity, which is one of the most promising methodologies. Besides, the polymers are made using MIT as the functional material of solid-phase extraction and chromatographic fractionating and sensor, because of the characteristics of the high selectivity, the better stability and easy preparation. This rev...
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In this study molecular imprinting technology was employed to prepare a specific affinity sorbent for the resolution of Methylephedrine, a chiral drug. The molecularly imprinted polymer (MIP) was prepared by non-covalent molecular imprinting with either (+) or (-)-Methylephedrine ((R*,S*)-2-(methylamino)-1phenylpropan-1-ol) as the template. Methacrylic acid and ethylene glycol di-methacrylate w...
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Molecularly imprinted polymers are synthetic polymers possessing specific cavities designed for target molecules. They are prepared by copolymerization of a cross-linking agent with the complex formed from a template and monomers that have functional groups specifically interacting with the template through covalent or noncovalent bonds. Subsequent removal of the imprint template leaves specifi...
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ژورنال
عنوان ژورنال: TrAC Trends in Analytical Chemistry
سال: 2018
ISSN: 0165-9936
DOI: 10.1016/j.trac.2018.01.011